Download PDF by Chi-Chao Chan: Animal Models of Ophthalmic Diseases


By Chi-Chao Chan

ISBN-10: 331919433X

ISBN-13: 9783319194332

ISBN-10: 3319194348

ISBN-13: 9783319194349

This e-book describes experimental animal versions that mimic universal human ocular ailments: herpetic keratitis, cataract, glaucoma, age-related macular degeneration, diabetic retinopathy, uveitis, retinitis pigmentosa, Graves’ sickness, and intraocular tumors. In conjunction, those types replicate the variety and software of instruments used to check human illness. global specialist clinicians speak about each one version in keeping with their medical adventure and the textual content is supported via a variety of images and diagrams. In describing the main pertinent animal types of ophthalmic ailments, this publication might be of curiosity to ophthalmologists, imaginative and prescient researchers, fellows, citizens and scientific students.

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Example text

A number of plant-derived, natural products known to inhibit AR activity have been explored as well as intrinsic ARI-containing extracts obtained from human kidney and bovine lenses (Kador et al. 2001). These studies provide evidence that ARIs may prevent and delay diabetic cataract formation. 1). In the dog, cataract, lens rupture, and lens-induced uveitis are well-known consequences of spontaneous and induced diabetes (Zeiss 2013). Importantly, the topical ARI drug, Kinostat has shown promise in its ability to reverse early sugar cataract development in dogs (Kador et al.

2010a). 1). Initially, studies using animal models confirmed the effect of high oxygen exposure on nuclear opacification. The main model for this has been the guinea pig, which when exposed to multiple treatments of HBO over extended periods of time exhibited lenses with increased nuclear scatter, along with protein insolubilization and increased levels of oxidized glutathione in the lens nucleus (Giblin et al. 1995; Bantseev et al. 2004; Gosselin et al. 2007). Studies using both cats and rats have shown the importance of the vitreous in protecting the lens from increased oxygen levels.

Nat Genet 12(2):212–215. 1038/ ng0296-212 Shiels A, Hejtmancik JF (2007) Genetic origins of cataract. Arch Ophthalmol 125(2):165–173. 165 Shiels A, Mackay D, Ionides A, Berry V, Moore A, Bhattacharya S (1998) A missense mutation in the human connexin50 gene (GJA8) underlies autosomal dominant “zonular pulverulent” cataract, on chromosome 1q. Am J Hum Genet 62(3):526–532. 1086/301762 Shiels A, Bassnett S, Varadaraj K, Mathias R, AlGhoul K, Kuszak J, Donoviel D, Lilleberg S, Friedrich G, Zambrowicz B (2001) Optical dysfunction of the crystalline lens in aquaporin-0-deficient 27 mice.

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Animal Models of Ophthalmic Diseases by Chi-Chao Chan

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