Download e-book for iPad: Animal Models in Eye Research by Panagiotis Antonios Tsonis
By Panagiotis Antonios Tsonis
The attention is a fancy sensory organ, which allows visible belief of the area. hence the attention has numerous tissues that do diverse projects. essentially the most simple features of eye functionality is the sensitivity of cells to mild and its transduction although the optic nerve to the mind. diverse organisms use other ways to accomplish those initiatives. during this feel, eye functionality turns into an important evolutionary point to boot. This booklet provides the various animal types which are normal for eye examine and their specialty in comparing varied features of eye improvement, evolution, body structure and sickness. * provides details at the significant animal versions utilized in eye examine together with invertebrates and vertebrates* presents researchers with details had to choose from version organisms* contains an introductory bankruptcy at the kinds of eyes, stressing attainable universal molecular equipment
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Extra resources for Animal Models in Eye Research
Current Pharmaceutical Design 14:116–125. Treisman JE (1999). A conserved blueprint for the eye? Bioessays 21:843–850. Umesono Y, Watanabe K, Agata K (1997). A planarian orthopedia homolog is specifically expressed in the branch region of both the mature and regenerating brain. Dev Growth Differ 39:723–727. Umesono Y, Watanabe K, Agata K (1999). Distinct structural domains in the planarian brain defined by the expression of evolutionarily conserved homeobox genes. Dev Genes Evol 209:31–39. Vandendries E, Johnson D, Reinke R (1996).
Notch acts during later stages to repress Ato expression. The fibronectin-like secreted protein Scabrous (Sca) interacts with Notch and is required to control proper ato expression (Fig. 6B). Sca is expressed in a subset of Ato cells in the intermediate group and remains expressed at high levels in R8. , 1990a). , 2001). The homeodomain transcription factor Rough (Ro) is activated in non-R8 cells due to lateral inhibition. , 2001). Conversely, the transcription factors senseless (sens) act in R8 to repress Ro.
7C). R7 receives the Notch signal from its neighboring cells R1 and R6; if this signal is absent, R7 differentiates into an R1/R6-like cell expressing BarH1 (Cooper and Bray, 1999; Tomlinson and Struhl, 2001). , 2003). Cell-cycle Control and Apoptosis in the Eye A tight control of proliferation as well as the elimination of supernumerous cells by controlled cell death, or apoptosis, is of great importance for proper eye formation. Initially, all eye imaginal disc cells proliferate in a seemingly uncoordinated manner before cells are patterned by the passage of the morphogenetic furrow.
Animal Models in Eye Research by Panagiotis Antonios Tsonis