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By A. Sonnenberg, A. Sengupta, P. Bauerfeind (auth.), W. D. W. Rees MD, MRCP (eds.)
Over the prior decade loads of learn task has happened on both sides of the gastroduodenal epithelial interface, with the typical target of elucidating the mechanisms of mucosal safety and the way those might be compromised in peptic ulcer sickness. a first-rate stimulus to such study has been the belief that irregular acid secretion or its supply into the duodenum in over the top quantity can't totally clarify ulcer pathogenesis within the majority of sufferers. One may well envisage the tummy and proximal duodenum as being in a dynamic equilibrium, with competitive luminal elements, corresponding to acid and pepsin, being counteracted through protecting mucosal mechanisms. till lately, the mechanisms enthusiastic about mucosal security were poorly outlined whereas the body structure and pathophysiology of acid and pepsin secretion were elucidated. The impact that gastroduodenal mucosa was once secure via a unmarried mechanism has finally been changed via a extra real looking view, suggesting a couple of protecting zones appearing in sequence. a few of these zones might act as first or moment line defences opposed to competitive elements whereas yes zones might in particular defend opposed to definite aggressors.
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Extra resources for Advances in Peptic Ulcer Pathogenesis
24-hour plasma gastrin concentration The technique for the measurement of 24-hour intragastric acidity has recently been used to correlate plasma polypeptide hormone levels with intragastric acidity24-26. Obviously, such a correlation would be useless in any study that involves intragastric titration with alkali. 10). All groups, except the pernicious anaemia patients, showed a prompt rise of plasma gastrin concentration in response to each of the three main meals. The pernicious anaemia patients, neither as a group nor as individuals, showed any gastrin response to the three main meals and throughout the 24 hours plasma gastrin concentration was constantly elevated.
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Advances in Peptic Ulcer Pathogenesis by A. Sonnenberg, A. Sengupta, P. Bauerfeind (auth.), W. D. W. Rees MD, MRCP (eds.)