2008-2009 Basic and Clinical Science Course: Section 9: by Ramana S. Moorthy, MD PDF
By Ramana S. Moorthy, MD
A dialogue of the medical method of uveitis ends up in broadly rewritten chapters on noninfectious (autoimmune) and infectious varieties of uveitis. additionally coated are endophthalmitis, masquerade syndromes, and issues of uveitis. A dialogue on ocular involvement in AIDS has been up-to-date. The part on immunology describes the human immune reaction in phrases that make it hugely obtainable to readers.
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Additional info for 2008-2009 Basic and Clinical Science Course: Section 9: Intraocular Inflammation and Uveitis (Basic and Clinical Science Course 2008-2009)
Preconditions necessary for processing Helper T lymphocytes are the key functional cell type for immune processing. Most helper T lymphocytes express CD4 molecules on the cell membrane. T lymphocytes have an antigen receptor that detects antigen only when a trimolecular complex is formed consisting of an APC- HLA molecule, a processed antigen fragment, and aT-lymphocyte antigen receptor. The CD4 molecule stabilizes binding and enhances signaling between the HLA complex and the T-lymphocyte receptor.
Chapter 4 discusses these mechanisms in greater detail. See also Part IV of BCSC Section 8, External Disease and Cornea. Immunoregulatory Systems The most important immunoregulatory system for the conjunctiva is called mucosaassociated lymphoid tissue (MALT). The MALT concept refers to the interconnected network of mucosal sites (the epithelial lining of the respiratory tract, gut, and genitourinary tract and the ocular surface and its adnexae) that share certain specific immunologic features: .
4, With the help of costimulatory molecules such as CD28/B7 interactions and cytokines, the CD4 T lymphocyte becomes primed, or partially activated. ) CHAPTER 2: Immunization and Adaptive Immunity. 21 Class I MHC molecules (ie, HLA-A, -8, and -C) serve as the antigen-presenting platform for CDS, or regulatory, T lymphocytes (Fig 2-3). Class I molecules are present on almost all nucleated cells, indicating that most cells have the potential to stimulate CDS T lymphocytes. The CDS T-lymphocyte antigen receptor must recognize its own class I type before it can respond to tumor or viral antigens on the appropriate target cell, and therefore CDS T lymphocytes from 1 individual will not respond to a target cell 1 2 HLA class I molecule Infected APC 4 3 Costimulation Antigen receptor CD8 T Lymphocyte Figure 2-3 Class I-dependent antigen-presenting cells (APCs).
2008-2009 Basic and Clinical Science Course: Section 9: Intraocular Inflammation and Uveitis (Basic and Clinical Science Course 2008-2009) by Ramana S. Moorthy, MD